Young but strong! 2023 Umbilical Biologics Summary

Yes, you read that right! InphiBio is young, but we are "young and talented": members of the project team have been working on single-cell and spatial genomics projects since 2016; members of the lab team have been working on spatial proteomics-related experiments for almost four years;

An Introduction to IVD Corporate Compliance

Based on the national public health epidemic prevention needs and encourage the development of IVD industry policy released one after another, China's IVD industry ushered in a new development opportunities. In order to reduce IVD...

Invitation | You are invited to the 2nd TICSSO International Conference on Single Cell and Spatial Histology.

Inphi Bio will bring spatial proteome (IMC, CODEX, mIHC), spatial transcriptome (10x Visium CytAssist) and related products to the 2023 TICSSO-2 Hangzhou Summit, and we welcome all the experts and scholars to visit our booth for exchange of information, and a variety of goodies will be given away for free!

New-age pathology techniques: spatial histology

Spatial genomics is another biotechnology research hotspot after single-cell sequencing technology, which can make up for the shortcomings of single-cell sequencing technology that cannot obtain the information of cell spatial distribution. Spatial genomics aims to map the molecular biology information of cells in a 3D environment, which can be used to reveal the influence of cell spatial distribution relationships on diseases, and currently the main tests are proteins and RNA.

Clinical Trial Programmes | CODEX reveals microenvironmental ecology of TLSs in chronic blisters of pemphigus

Pemphigus is a rare life-threatening autoimmune disease that presents as blisters and erosions on the skin and/or mucous membranes. Although tertiary lymphoid structures (TLSs ) have been detected in the inflammatory lesions of patients with pemphigus, the role of TLSs in the pathogenesis of pemphigus remains unclear.

Recently, researchers from Yonsei University College of Medicine published a paper titled "Microenvironmental network of clonal CXCL13+CD4+ T cells and regulatory T cells in pemphigus" in the Journal of Clinical Investigation (IF=15.9). cells and regulatory T cells in pemphigus chronic blisters" in the Journal of Clinical Investigation (IF=15.9), revealing the presence of TLSs containing DSG-specific B cells and plasma cells and the up-regulation of CXCL13 expression in chronic blisters of pemphigus patients.

Nature Communications | Flip through the scRNA-seq dataset and add some IMC data analysis to give you a different high score experience!

Tumour-associated fibroblasts (CAF) are a diverse population of cells in the tumour microenvironment that have a significant impact on tumour evolution and patient prognosis.
To define CAF phenotypes, the researchers analysed a single-cell RNA sequencing (scRNA-seq) dataset of more than 16,000 mesenchymal stromal cells from the tumours of 14 breast cancer patients, on the basis of which nine CAF phenotypes and a class of pericytes were defined and functionally annotated. The researchers validated this classification system in four additional cancer types and used tissue imaging mass spectrometry flow (IMC) technology on matched breast cancer samples to confirm CAF phenotypes defined at the protein level and to analyse their spatial distribution in the tumour. This CAF classification scheme will allow comparison of CAF phenotypes from different studies, facilitate analysis of their functional role and potentially guide the development of new therapeutic strategies in the future.